The 27-nation bloc instituted an assets freeze and a visa ban on Mr. Assad and nine other members of his regime.
Earlier this month, the EU sanctioned 13 people with links to the Syrian regime, but Mr. Assad was not among them. A European official said at the time that the omission was part of a deliberately gradual approach.
But the killing of anti-government protesters has continued unabated. Syrian security forces opened fire on a funeral procession for slain anti-government protesters Saturday, pushing the number of people reported killed in the two-month uprising to more than 900 and making it one of the deadliest of the recent uprisings in the Arab world.
Georges Chachan, an exiled opposition figure, welcomed the sanctions on Mr. Assad.
“It was about time,” said Mr. Chachan, who is head of the Assyrian Democratic Organization–Belgium, although he acknowledged the sanctions would not force Mr. Assad from power.
“This was an important step because it’s a symbol,” he said. “Bashar al-Assad is the head of the system. He’s the head of the regime. So by doing so today, they said, ‘Well, the president is responsible for what’s happening in Syria — killing and so on.’ “
The sanctions are a significant personal blow to Mr. Assad, a British-educated, self-styled reformer who has made a high priority of efforts to bring Syria back into the global mainstream, efforts that included hosting a series of visits from European diplomats.
His wife, Asma, was born and raised in Britain and educated there. Earlier this month, the Syrian Embassy in London was forced to deny persistent rumors that she had fled to Britain with the couple’s young children.
EU foreign ministers, meeting Monday in Brussels, also adopted a statement that says “the EU condemns in the strongest terms the ongoing repression in Syria and the unacceptable violence used by the military and security forces against peaceful protesters.”
The statement said those responsible for the violence should be held accountable.
It urges the Syrian leadership to grant access to an urgent mission of the Office of the High Commissioner for Human Rights. And it expresses concern at mass arrests and torture and calls for the release of all political prisoners.
In addition, the statement says the EU is deeply troubled by the military closure of a number of Syrian cities, including Deraa, Banias and Homs, and by reports that access to medical care and basic services in those areas is being restricted.